在日本发现的三种葡萄糖-6-磷酸脱氢酶变体。
Three glucose 6-phosphate dehydrogenase variants found in Japan.
作者信息
Miwa S H, Nakashima K, Ono J, Fujii H, Suzuki E
出版信息
Hum Genet. 1977 May 10;36(3):327-34. doi: 10.1007/BF00446284.
Three Japanese glucose 6-phosphate dehydrogenase (G6PD) variants were investigated. G6PD 'Mediterranean-like' had markedly decreased activity, normal electrophoretic mobility, low Km G6P, low Km NADP, increased utilization of all three substrate analogues (2-deoxy-G6P, Gal-6P, and deamino-NADP) and slightly decreased heat stability and slightly biphasic pH curve. G6PD 'Ogori' had markedly decreased activity, but otherwise normal characteristics. G6PD 'Hofu' had moderately decreased activity, normal electrophoretic mobility, slightly reduced Km G6P, normal Km NADP, normal utilization of 2-deoxy-G6P and Gal-6P, but increased utilization of deamino-NADP and normal heat stability as well as normal pH curve.
对三种日本葡萄糖-6-磷酸脱氢酶（G6PD）变体进行了研究。“地中海样”G6PD活性显著降低，电泳迁移率正常，G6P的Km值低，NADP的Km值低，对所有三种底物类似物（2-脱氧-G6P、Gal-6P和脱氨基-NADP）的利用率增加，热稳定性略有降低，pH曲线略呈双相。“小织”G6PD活性显著降低，但其他特性正常。“府中”G6PD活性中度降低，电泳迁移率正常，G6P的Km值略有降低，NADP的Km值正常，对2-脱氧-G6P和Gal-6P的利用率正常，但对脱氨基-NADP的利用率增加，热稳定性正常，pH曲线正常。
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