重度抑郁症患者的血清素功能障碍与自杀未遂：一项听觉事件相关电位研究。
Serotonin dysfunction and suicide attempts in major depressives: an auditory event-related potential study.
作者信息
Chen Tai-Jui, Yu Younger W-Y, Chen Ming-Chao, Wang Shing-Yaw, Tsai Shih-Jen, Lee Tien-Wen
机构信息
Kai-Suan Psychiatric Hospital, Kaohsiung, Taiwan, ROC.
出版信息
Neuropsychobiology. 2005;52(1):28-36. doi: 10.1159/000086175. Epub 2005 Jun 3.
BACKGROUND
Serotonergic dysfunction is believed to be involved in suicide attempts. The loudness-dependent auditory evoked potential (LDAEP) is one of the validated indicators of the activity of the central serotonin system in humans.
OBJECTIVES
This study was designed to investigate possible differences in the LDAEP and P300 between those depressed patients who attempted suicide and those who did not.
METHODS
The LDAEP and P300 levels were recorded for 66 depressive patients (among which 16 had attempted suicide).
RESULTS
Those who had attempted suicide showed a sharper slope of the LDAEP and increased frontal P300 amplitude. A high correlation between the LDAEP and P300, and a gender difference were also noted.
CONCLUSIONS
Our results are concordant with previous assumptions about serotonin dysfunction in depressives who attempt suicide.
背景
血清素功能障碍被认为与自杀未遂有关。响度依赖性听觉诱发电位（LDAEP）是人类中枢5-羟色胺系统活动的有效指标之一。
目的
本研究旨在调查自杀未遂的抑郁症患者与未自杀未遂的抑郁症患者之间LDAEP和P300的可能差异。
方法
记录了66名抑郁症患者（其中16名有自杀未遂史）的LDAEP和P300水平。
结果
自杀未遂者的LDAEP斜率更陡，额叶P300波幅增加。还发现LDAEP与P300之间存在高度相关性以及性别差异。
结论
我们的结果与之前关于自杀未遂抑郁症患者血清素功能障碍的假设一致。
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