Musella M, Fazioli F, Lombardi S, Servodio C I, De Martino C, Iacono V, Cigala F, Jovino R
Department of General and Emergency Surgery, Federico II University Medical School, 80131 Naples, Italy.
Surg Endosc. 2005 Aug;19(8):1120-4. doi: 10.1007/s00464-004-2094-6. Epub 2005 May 12.
This study was designed to test cyclin D1 as a prognostic marker in patients with soft tissue sarcomas (STS), and to evaluate the usefulness of laparoscopy for determining cyclin D1 overexpression.
The records of 62 patients with STS were collected: 28 with retroperitoneal STS (RSTS) and 34 with extremity STS (ESTS). A total of 51 patients underwent surgical resection, whereas 11 did not undergo surgery because of advanced tumor stage. Preoperative-intraoperative laparoscopic staging was performed for patients judged to be resectable at preoperative imaging.
Cyclin D1 was overexpressed in 30 (58.8%) of 51 resected patients and in 10 (90.9%) of 11 nonresected patients. Laparoscopy avoided unnecessary laparotomy in 9 (32.1%) of 28 RSTS patients.
High tumor grade, positive surgical margins, local recurrence, distant metastases, and cyclin D1 overexpression were related to poor survival. Multivariate analysis demonstrated cyclin D1 to be the only independent factor. Laparoscopy was shown to be useful for avoiding useless laparotomies.
本研究旨在检测细胞周期蛋白D1作为软组织肉瘤（STS）患者的预后标志物，并评估腹腔镜检查在确定细胞周期蛋白D1过表达方面的实用性。
收集62例STS患者的记录：28例为腹膜后STS（RSTS），34例为肢体STS（ESTS）。共有51例患者接受了手术切除，而11例因肿瘤分期较晚未接受手术。对术前影像学检查判断可切除的患者进行术前-术中腹腔镜分期。
在51例接受手术切除的患者中，30例（58.8%）细胞周期蛋白D1过表达，在11例未接受手术的患者中，10例（90.9%）过表达。腹腔镜检查避免了28例RSTS患者中9例（32.1%）进行不必要的剖腹手术。
高肿瘤分级、手术切缘阳性、局部复发、远处转移和细胞周期蛋白D1过表达与生存率低有关。多因素分析表明细胞周期蛋白D1是唯一的独立因素。腹腔镜检查被证明有助于避免不必要的剖腹手术。
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