Kokudo Norihiro, Sugawara Yasuhiko, Imamura Hiroshi, Sano Keiji, Makuuchi Masatoshi
Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, University of Tokyo, Japan.
Am J Transplant. 2005 Jul;5(7):1694-703. doi: 10.1111/j.1600-6143.2005.00917.x.
Donor hepatectomies for adult living donor liver transplantations were performed in 200 consecutive donors to harvest a left liver (LL) graft (n = 5), a LL plus caudate lobe (LL + CL) graft (n = 63), a right liver (RL) graft (n = 86), a RL and middle hepatic vein (RL + MHV) graft (n = 28) or a right lateral sector (RLS) graft (n = 18). The graft type was selected so that at least 40% of the recipient's standard liver volume was harvested. No donor deaths occurred, and no significant differences in the morbidity rates among either donors or recipients were observed when the outcomes were stratified according to the graft type. Donors who donated RL exhibited higher values of serum total bilirubin and prothrombin time than those who donated non-RL (LL, LL + CL, RLS) grafts. The time taken for hilar dissection and parenchymal transection increased in the following order: RLS graft, LL graft and RL graft harvesting. In conclusion, non-RL grafting was more time consuming, but the hepatic functional loss in the donors was smaller. Our graft selection criteria were useful for reducing the use of RL grafts with acceptable morbidity in both donors and recipients.
对200例成年活体供肝移植的供体进行肝切除术,获取左肝(LL)移植物(n = 5)、左肝加尾状叶(LL + CL)移植物(n = 63)、右肝(RL)移植物(n = 86)、右肝及肝中静脉(RL + MHV)移植物(n = 28)或右外侧叶(RLS)移植物(n = 18)。选择移植物类型时,要保证获取的移植物体积至少达到受体标准肝体积的40%。供体无死亡病例,根据移植物类型对结果进行分层时,未观察到供体或受体的发病率存在显著差异。捐献右肝的供体血清总胆红素和凝血酶原时间值高于捐献非右肝(LL、LL + CL、RLS)移植物的供体。肝门解剖和实质离断所需时间按以下顺序增加:RLS移植物、LL移植物和RL移植物获取。总之,非右肝移植耗时更长,但供体肝功能损失更小。我们的移植物选择标准有助于减少右肝移植物的使用,且供体和受体的发病率均可接受。