左乙拉西坦在实验性人体疼痛模型中的特定作用。
Specific effect of levetiracetam in experimental human pain models.
作者信息
Enggaard Thomas P, Klitgaard Niels A, Sindrup Søren H
机构信息
Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense University, Winslowparken 19, DK-5000 Odense C, Denmark.
出版信息
Eur J Pain. 2006 Apr;10(3):193-8. doi: 10.1016/j.ejpain.2005.03.011. Epub 2005 Jun 8.
BACKGROUND
Levetiracetam is a new antiepileptic drug. There is only limited experience with levetiracetam in clinical neuropathic pain.
AIM
To test the analgesic effect of levetiracetam in a human experimental pain model in order to obtain preclinical evidence for its potential effect in neuropathic pain.
METHODS
Sixteen healthy volunteers completed a randomized, double-blind, cross-over trial with a single oral dose of 1500 mg levetiracetam against placebo. Pain tests included pain detection and tolerance to single electrical stimulation and temporal pain summation threshold to repetitive electrical stimulation (3 Hz) of the sural nerve.
RESULTS
Levetiracetam significantly increased the pain tolerance thresholds (p=0.04), and the pain detection thresholds tended to be increased (p=0.06), whereas levetiracetam had no effect on temporal pain summation thresholds (p=0.30).
CONCLUSION
Levetiracetam has an analgesic effect in the electrical sural nerve stimulation pain model, but it did not increase temporal pain summation threshold. Levetiracetam may still be effective in clinical neuropathic pain.
背景
左乙拉西坦是一种新型抗癫痫药物。左乙拉西坦在临床神经性疼痛方面的经验有限。
目的
在人体实验性疼痛模型中测试左乙拉西坦的镇痛效果，以便获得其在神经性疼痛中潜在作用的临床前证据。
方法
16名健康志愿者完成了一项随机、双盲、交叉试验，单次口服1500毫克左乙拉西坦并与安慰剂对照。疼痛测试包括对单次电刺激的疼痛检测和耐受性，以及对腓肠神经重复电刺激（3赫兹）的时间性疼痛总和阈值。
结果
左乙拉西坦显著提高了疼痛耐受阈值（p = 0.04），疼痛检测阈值有升高趋势（p = 0.06），而左乙拉西坦对时间性疼痛总和阈值无影响（p = 0.30）。
结论
左乙拉西坦在电刺激腓肠神经疼痛模型中有镇痛作用，但未提高时间性疼痛总和阈值。左乙拉西坦在临床神经性疼痛中可能仍然有效。
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