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一名年轻女性的自发性冠状动脉夹层:从急诊冠状动脉旁路移植术到心脏移植

Spontaneous coronary artery dissection in a young woman: from emergency coronary artery bypass grafting to heart transplantation.

作者信息

Ferrari Enrico, Tozzi Piergiorgio, von Segesser Ludwig Karl

机构信息

Department of Cardiovascular Surgery, Centre Hôpitalier Universitaire Vaudois (CHUV), 46 Rue du Bugnon, CH-1011 Lausanne, Switzerland.

出版信息

Eur J Cardiothorac Surg. 2005 Aug;28(2):349-51. doi: 10.1016/j.ejcts.2005.04.035.

Abstract

Primary spontaneous coronary artery dissection (SCAD) as cause of acute myocardial infarction is a rare entity with complex pathophysiology. SCAD must be considered every time that a healthy young patient presents an onset of acute myocardial ischemic syndrome or sudden death. Mostly it appears in young women without traditional risk factors for coronary artery disease and a significant proportion of them are hutted during the peripartum or early postpartum period. SCAD is frequently fatal and a great number of known cases have been diagnosed at necroscopy. The quick recognition of SCAD as cause of acute myocardial ischemia in a young patient is important to establish the best medical/surgical treatment between the different therapeutic attitudes. We describe the case occurred to a young low cardiac risk woman who suffered of idiopathic SCAD and was successfully treated by heart transplantation few days after that a conventional surgical myocardial revascularization had been attempted. Waiting for cardiac transplantation the patient survived several days, thanks to a mechanical left ventricular assist device (LVAD). The following hospital course was uncomplicated. To our knowledge, this is the second case of SCAD treated successfully by LVAD and orthotopic heart transplantation reported in literature.

摘要

原发性自发性冠状动脉夹层(SCAD)作为急性心肌梗死的病因是一种罕见的疾病,其病理生理过程复杂。每当健康的年轻患者出现急性心肌缺血综合征或猝死时,都必须考虑到SCAD。它大多出现在没有冠状动脉疾病传统危险因素的年轻女性中,其中很大一部分在围产期或产后早期发病。SCAD往往是致命的,大量已知病例是在尸检时被诊断出来的。快速识别SCAD作为年轻患者急性心肌缺血的病因,对于在不同治疗态度之间确定最佳的药物/手术治疗方法很重要。我们描述了一名低心脏风险的年轻女性发生特发性SCAD的病例,在尝试进行传统的外科心肌血运重建几天后,该患者成功接受了心脏移植治疗。在等待心脏移植期间,得益于机械左心室辅助装置(LVAD),患者存活了数天。随后的住院过程顺利。据我们所知,这是文献中报道的第二例通过LVAD和原位心脏移植成功治疗的SCAD病例。

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