Tsui Po-Hsiang, Wang Shyh-Hau, Huang Chih-Chung
Department of Biomedical Engineering, Yuan Pei Institute of Science and Technology, 306, Yuanpei St., Hsin Chu 30015, Taiwan.
Ultrasonics. 2005 Jun;43(7):560-5. doi: 10.1016/j.ultras.2004.12.003. Epub 2004 Dec 18.
The effect of ultrasound at various energy levels on the conduction properties of neural tissue is explored in this in vitro study. Excised sciatic nerves from the bullfrog were used for experiments. The nerves were stimulated by 3.5 MHz continuous wave ultrasound at 1, 2, and 3 W for 5 min. The peak-to-peak amplitude of the electrically evoked compound action potential (CAP) and the conduction velocity (CV) were measured in the nerves before and during ultrasound stimulation. The CV of the nerves increased by 5-20% for ultrasound stimulations at 1-3 W. The CAP amplitude increased by 8% during stimulation with 1 W ultrasound, and progressively decreased for 2 and 3 W ultrasound. This indicates that the effect of lower energy ultrasound increases both the CV and the CAP amplitude and that the reduction in the CAP amplitude for higher energy ultrasound is associated largely with ultrasonic thermal effects.
在这项体外研究中，探究了不同能量水平的超声波对神经组织传导特性的影响。实验使用了从牛蛙身上切除的坐骨神经。神经由3.5兆赫连续波超声以1瓦、2瓦和3瓦的功率刺激5分钟。在超声刺激之前和期间，测量神经中电诱发复合动作电位（CAP）的峰峰值幅度和传导速度（CV）。对于1 - 3瓦的超声刺激，神经的CV增加了5 - 20%。在1瓦超声刺激期间，CAP幅度增加了8%，而对于2瓦和3瓦的超声刺激，CAP幅度逐渐降低。这表明较低能量的超声波既增加了CV也增加了CAP幅度，而较高能量超声波导致的CAP幅度降低在很大程度上与超声热效应有关。
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