Uthman Imad, Shamseddine Ali, Taher Ali
Department of Internal Medicine, Division of Rheumatology, American University of Beirut Medical Center (AUBMC), Hamra Street, Beirut 1107 2802, Lebanon.
Transfus Apher Sci. 2005 Aug;33(1):11-7. doi: 10.1016/j.transci.2004.10.025.
The catastrophic antiphospholipid syndrome (CAPS) is a life-threatening sub-entity of the antiphospholipid syndrome (APS) resulting in multiorgan failure and a mortality rate that may reach 50%. The optimal treatment regimen for CAPS is unknown. To evaluate the benefit of therapeutic plasma exchange (TPE) therapy in CAPS, we undertook a computer-assisted (MEDLINE, National Library of Medicine, Bethesda, MD) search of the literature to locate all cases of CAPS (case reports and reviews) treated with TPE. In view of the published literature so far, TPE has shown reasonable therapeutic benefits and improved survival for patients with CAPS. The use of this technique, along with anticoagulation and if needed pharmacological immunosuppression, should be considered for the acute management of patients who present with this life-threatening condition.
灾难性抗磷脂综合征（CAPS）是抗磷脂综合征（APS）中一种危及生命的亚型，可导致多器官功能衰竭，死亡率可达50%。CAPS的最佳治疗方案尚不清楚。为评估治疗性血浆置换（TPE）疗法对CAPS的疗效，我们通过计算机辅助（检索美国国立医学图书馆的MEDLINE数据库，位于马里兰州贝塞斯达）对文献进行检索，以查找所有接受TPE治疗的CAPS病例（病例报告和综述）。鉴于目前已发表的文献，TPE已显示出对CAPS患者具有合理的治疗益处并能提高生存率。对于出现这种危及生命状况的患者的急性处理，应考虑使用该技术，同时进行抗凝治疗，并根据需要进行药物免疫抑制治疗。
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