Howell Gina M S, Grandis Jennifer R
Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, The Eye and Ear Institute Building, Suite 500, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
Head Neck. 2005 Aug;27(8):710-7. doi: 10.1002/hed.20222.
The presence of regional metastasis in patients with head and neck squamous cell carcinoma (HNSCC) is a common and adverse event associated with poor prognosis and high mortality. Although significant improvements in standard therapies have increased the efficacy of local tumor management, the high incidence of tumor recurrence has resulted in limited improvements in overall survival rates. Understanding the molecular mechanisms that mediate HNSCC invasion and metastasis may enable identification of novel therapeutic targets for the prevention and management of tumor dissemination.
A literature review was performed.
Several biologic mediators and mechanisms that have been implicated in HNSCC metastasis, such as cell adhesion molecules, proteolytic enzymes, growth factor signaling, metastasis suppressor genes, and chemokine receptors were reviewed.
Prevention of HNSCC metastasis is an important clinical objective that requires an increased understanding of the molecular mechanisms of tumor invasion and dissemination.
头颈部鳞状细胞癌（HNSCC）患者出现区域转移是一种常见的不良事件，与预后不良和高死亡率相关。尽管标准治疗方法有了显著改进，提高了局部肿瘤管理的疗效，但肿瘤复发的高发生率导致总体生存率的改善有限。了解介导HNSCC侵袭和转移的分子机制可能有助于识别预防和管理肿瘤播散的新治疗靶点。
进行了文献综述。
综述了几种与HNSCC转移有关的生物介质和机制，如细胞粘附分子、蛋白水解酶、生长因子信号传导、转移抑制基因和趋化因子受体。
预防HNSCC转移是一项重要的临床目标，需要更多地了解肿瘤侵袭和播散的分子机制。
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