过度劳累会阻碍你的成长。

Getting RIP'd Stunts Your Growth.

作者信息

Ceni Claire, Barker Philip A

机构信息

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada.

出版信息

Neuron. 2005 Jun 16;46(6):839-40. doi: 10.1016/j.neuron.2005.06.002.

DOI:10.1016/j.neuron.2005.06.002

PMID:15953410

Abstract

The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RIP) of p75NTR and find that p75NTR cleavage is required for MAG-induced RhoA activation and growth inhibition.

摘要

p75神经营养因子受体（p75NTR）与Nogo受体（NgR）和LINGO-1协同作用，以响应基于髓磷脂的生长抑制剂（如髓磷脂相关糖蛋白（MAG））激活RhoA。在本期《神经元》杂志中，多梅尼科尼等人出人意料地发现，MAG可诱导p75NTR的膜内蛋白水解（RIP），并发现p75NTR的裂解是MAG诱导的RhoA激活和生长抑制所必需的。