通过铱（I）/锌（II）双金属催化的烯丙基醚化反应。

Allylic etherification via Ir(I)/Zn(II) bimetallic catalysis.

作者信息

Roberts Justin P, Lee Chulbom

机构信息

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.

出版信息

Org Lett. 2005 Jun 23;7(13):2679-82. doi: 10.1021/ol0508328.

DOI:10.1021/ol0508328

Abstract

[reaction: see text] An efficient allylic etherification of aliphatic alcohols with allylic carbonates has been achieved by an iridium catalysis using stoichiometric zinc alkoxides or a two-component bimetallic catalytic system where the Ir(I) catalyst acts on allylic carbonates to generate electrophiles while aliphatic alcohols are separately activated by Zn(II) coordination to function as nucleophilies. This reaction occurs with complete regiospecificity and tolerates a wide range of functional groups.

摘要

[反应：见正文] 通过使用化学计量的醇盐锌或双组分双金属催化体系的铱催化，实现了脂肪醇与碳酸烯丙酯的高效烯丙基醚化反应。在该反应中，Ir(I)催化剂作用于碳酸烯丙酯生成亲电试剂，而脂肪醇通过与Zn(II)配位被单独活化作为亲核试剂。该反应具有完全的区域特异性，并且能耐受多种官能团。

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