供体肾移植质量与移植排斥反应之间的关系
[Relationship between donor renal graft quality and graft rejection].
作者信息
Yu Li-xin, Zeng Jing-hua, Fu Shao-jie, Miao Yun, Ye Gui-rong, DU Zheng-ping, Han Cong-xiang
机构信息
Department of Kidney Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2005 Jun;25(6):700-2.
OBJECTIVE
To evaluate the correlation between the quality of donor renal grafts and graft rejection.
METHODS
The cold ischemia time and the pathological findings by biopsies of the donor grafts in 87 cases were analyzed in conjunction with the occurrence of acute or chronic graft rejection after transplantation.
RESULTS
After transplantation, acute rejection occurred in 28 cases, in which 5 (17.8%) had adverse changes in the donor grafts; chronic allograft nephropathy developed in 13 cases, in which 6 (46.1%) had adverse changes in the donor grafts. By binary logistic regression analysis, the cold ischemia time and acute renal tubular injury were identified as the factors affecting acute graft rejection, and cold ischemia time and glomeruloserosis as the risk factors for chronic rejection.
CONCLUSION
High-quality donor kidney and minimization of the risk factors help reduce the occurrence of graft rejection after kidney transplantation.
目的
评估供肾移植物质量与移植物排斥反应之间的相关性。
方法
分析87例供体移植物的冷缺血时间及活检病理结果，并结合移植后急性或慢性移植物排斥反应的发生情况进行分析。
结果
移植后，28例发生急性排斥反应，其中5例（17.8%）供体移植物有不良改变；13例发生慢性移植肾肾病，其中6例（46.1%）供体移植物有不良改变。通过二元逻辑回归分析，确定冷缺血时间和急性肾小管损伤为影响急性移植物排斥反应的因素，冷缺血时间和肾小球硬化为慢性排斥反应的危险因素。
结论
高质量的供肾及将危险因素降至最低有助于减少肾移植后移植物排斥反应的发生。
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