Zertuche J M, Brown M P, Gronwall R, Merritt K
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.
Am J Vet Res. 1992 Mar;53(3):372-4.
Pharmacokinetic values for flunixin meglumine (1 mg/kg of body weight) and phenylbutazone (4 mg/kg) dosages were determined after a single IV injection with and without concurrent intragastric administration of probenecid (50 mg/kg) in 6 healthy mares. Significant difference was not apparent in the pharmacokinetic values of flunixin meglumine with and without concurrent probenecid administration. Significant (P less than or equal to 0.05) increase was evident in the 12-hour mean concentration of phenylbutazone (11.45 +/- 1.66 micrograms/ml without probenecid; 14.56 +/- 1.20 micrograms/ml with probenecid) along with significant (P less than or equal to 0.05) reduction in its volume of distribution at steady state associated with concurrent probenecid administration (218.6 +/- 11.52 ml/kg without probenecid; 169.4 +/- 9.25 ml/kg with probenecid).
对6匹健康母马单次静脉注射氟尼辛葡甲胺（1毫克/千克体重）和保泰松（4毫克/千克）剂量后，在同时胃内给予丙磺舒（50毫克/千克）和不给予丙磺舒的情况下测定药代动力学值。给予和未给予丙磺舒时，氟尼辛葡甲胺的药代动力学值无明显差异。保泰松12小时平均浓度显著（P≤0.05）升高（未给予丙磺舒时为11.45±1.66微克/毫升；给予丙磺舒时为14.56±1.20微克/毫升），同时与给予丙磺舒相关的稳态分布容积显著（P≤0.05）降低（未给予丙磺舒时为218.6±11.52毫升/千克；给予丙磺舒时为169.4±9.25毫升/千克）。
Zotero 插件