Bunaciu Andrei A, Aboul-Enein Hassan Y, Fleschin Serban
ROMSPECTRA IMPEX SRL, Analytical Research Department, 25 Street Maguricea, PO Box 52-3, Bucharest, Romania.
Farmaco. 2005 Aug;60(8):685-8. doi: 10.1016/j.farmac.2005.05.008.
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of bucillamine. Conventional KBr-spectra and DRIFTS spectra were compared for best determination of active substance in its tablet formulation. Two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods were used in data processing. Similar results were obtained with both chemometric methods.
开发了一种傅里叶变换红外（FT-IR）光谱法，用于快速、直接测定布西拉明。比较了常规KBr光谱和漫反射红外傅里叶变换光谱（DRIFTS），以最佳测定其片剂制剂中的活性物质。在数据处理中使用了两种化学计量学方法，即偏最小二乘法（PLS）和主成分回归（PCR+）方法。两种化学计量学方法得到了相似的结果。
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