乙肝病毒疫苗接种：泰国医学生是否得到了充分保护？

Vaccination against hepatitis B virus: are Thai medical students sufficiently protected?

作者信息

Techasathit Wichai, Ratanasuwan Winai, Sonjai Areeaue, Sangsiriwut Kantima, Anekthananon Thanomsak, Suwanagool Surapol

机构信息

Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

出版信息

J Med Assoc Thai. 2005 Mar;88(3):329-34.

PMID:15962639

Abstract

Medical students are frequently at risk of being infected by hepatitis B virus (HBV) via occupational exposure to infected blood or body fluids. In 2002, the Faculty of Medicine, Siriraj Hospital provided screening tests for HBV serology to all medical students for a vaccination campaign against the infection. There were 1,165 medical students tested. Eight hundred and eleven (69.6%) students had immunity by previous vaccination, but more importantly 212 (18.2%) had no immunity and required vaccination. Most of the students who needed to be vaccinated were in the pre-clinical year (82.5%). Moreover, the students in the pre-clinical year who had previous vaccination had a 2.2 times greater risk of having negative anti-HBs than the students in the clinical year (OR = 2.2, 95% CI = 1.4-3.5). This is because they might have been vaccinated when they were young and the antibody waned overtime.

摘要

医学生经常面临因职业接触受感染血液或体液而感染乙型肝炎病毒（HBV）的风险。2002年，诗里拉吉医院医学院为所有医学生提供了HBV血清学筛查测试，以开展针对该感染的疫苗接种活动。共有1165名医学生接受了检测。811名（69.6%）学生因之前接种过疫苗而具有免疫力，但更重要的是，212名（18.2%）学生没有免疫力，需要接种疫苗。大多数需要接种疫苗的学生处于临床前学年（82.5%）。此外，临床前学年中之前接种过疫苗的学生抗-HBs呈阴性的风险是临床学年学生的2.2倍（OR = 2.2，95% CI = 1.4 - 3.5）。这是因为他们可能在年幼时接种过疫苗，随着时间推移抗体逐渐减弱。