高同型半胱氨酸血症作为深静脉血栓形成的一个风险因素。

Hyperhomocysteinaemia as a risk factor for deep-vein thrombosis.

作者信息

Unlü Y, Keleş S, Becit N, Koçoğullari C U, Koçak H, Bakan E

机构信息

Department of Cardiovascular Surgery, Atatürk University, Erzurum, Turkey.

出版信息

Eur J Vasc Endovasc Surg. 2005 Sep;30(3):315-8. doi: 10.1016/j.ejvs.2005.05.002.

DOI:10.1016/j.ejvs.2005.05.002

PMID:15963742

Abstract

OBJECTIVE

Several studies have shown a relation between hyperhomocysteinaemia and vascular disease. To assess the risk of deep-vein thrombosis (DVT) associated with hyperhomocysteinaemia, we studied plasma homocysteine levels in patients with deep-vein thrombosis and in normal control subjects.

MATERIALS AND METHODS

We measured plasma homocysteine levels in 48 patients with deep-vein thrombosis and in 33 healthy controls matched to the patients according to age and sex. Plasma homocysteine levels were measured with high performance liquid chromatography and fluorescence detection. Hyperhomocysteinaemia was defined as a plasma homocysteine level about 15 micromol/L in both groups. The diagnosis of all patients with deep-vein thrombosis (n=48) was verified by Doppler ultrasonography.

RESULTS

Plasma homocysteine levels were found to be increased in the deep-vein thrombosis group compared the control group (p<0.001, t-test). The mean plasma homocysteine level in the patients was 17.1 SD 5.13 micromol/L (range 6.4-31.3), and that in the controls was 9.0 SD 1.27 micromol/L (range 6.0-11.5). The association between elevated homocysteine levels and venous thrombosis was stronger among men than among women.

CONCLUSIONS

The increased plasma homocysteine levels we have observed may have a causative role in the development of deep-vein thrombosis.

摘要

目的

多项研究表明高同型半胱氨酸血症与血管疾病之间存在关联。为评估与高同型半胱氨酸血症相关的深静脉血栓形成（DVT）风险，我们研究了深静脉血栓形成患者和正常对照者的血浆同型半胱氨酸水平。

材料与方法

我们测量了48例深静脉血栓形成患者以及33名根据年龄和性别与患者匹配的健康对照者的血浆同型半胱氨酸水平。采用高效液相色谱法和荧光检测法测量血浆同型半胱氨酸水平。两组中，高同型半胱氨酸血症均定义为血浆同型半胱氨酸水平高于15微摩尔/升。所有深静脉血栓形成患者（n = 48）的诊断均通过多普勒超声检查得以证实。

结果

与对照组相比，深静脉血栓形成组的血浆同型半胱氨酸水平升高（p < 0.001，t检验）。患者的平均血浆同型半胱氨酸水平为17.1 ± 5.13微摩尔/升（范围6.4 - 31.3），对照组为9.0 ± 1.27微摩尔/升（范围6.0 - 11.5）。同型半胱氨酸水平升高与静脉血栓形成之间的关联在男性中比在女性中更强。