Jaffé Adam, Balfour-Lynn Ian M
Portex Respiratory Medicine Group, Great Ormond Street Hospital for Children, National Health System Trust and Institute of Child Health, London, UK.
Pediatr Pulmonol. 2005 Aug;40(2):148-56. doi: 10.1002/ppul.20251.
The incidence of empyema complicating community-acquired pneumonia is increasing and causes significant childhood morbidity. Pneumococcal infection remains the most common isolated cause in developed countries, with Staphylococcus aureus the predominant pathogen in the developing world. Newer molecular techniques utilizing the polymerase chain reaction have led to an increase in identification of causative bacteria, previously not isolated by conventional culture techniques. This remains an important epidemiological tool, and may help in guiding correct antibiotic use in the future. There are many treatment options, however, and the care a child currently receives is dependent on local practice, which is largely determined by availability of medical personnel and their preferences. Although there are many reported case series comparing treatment options, only two randomized controlled studies exist to guide treatment in children. There is an urgent need for this to be addressed, particularly with the introduction of relatively new surgical techniques such as video-assisted thorascopic surgery.
脓胸并发社区获得性肺炎的发病率正在上升,并导致儿童出现严重发病情况。在发达国家,肺炎球菌感染仍然是最常见的单一病因,而在发展中世界,金黄色葡萄球菌是主要病原体。利用聚合酶链反应的新型分子技术已使此前无法通过传统培养技术分离出的致病细菌的识别率有所提高。这仍然是一项重要的流行病学工具,可能有助于在未来指导正确使用抗生素。然而,治疗选择众多,目前儿童所接受的护理取决于当地的做法,这在很大程度上由医务人员的可获得性及其偏好决定。尽管有许多报告的病例系列比较了治疗选择,但仅有两项随机对照研究可用于指导儿童治疗。迫切需要解决这一问题,尤其是随着视频辅助胸腔镜手术等相对较新的外科技术的引入。