维甲酸诱导人神经母细胞瘤细胞分化过程中纤连蛋白合成的调节
Modulation of laminin synthesis in human neuroblastoma cells during retinoic acid induced differentiation.
作者信息
Scarpa S, D'Orazi G, Ragano-Caracciolo M, Cardelli P, Masuelli L, Modesti A
机构信息
Experimental Medicine Department, University of Rome La Sapienza, Italy.
出版信息
Cancer Lett. 1992 May 30;64(1):31-7. doi: 10.1016/0304-3835(92)90018-q.
A comparable pattern of morphological neuronal differentiation was induced in the human neuroblastoma cell line SMS-KCNR by treatment with either retinoic acid (RA) or exogenous laminin (LM). LM expression and synthesis by SMS-KCNR was increased upon RA treatment which involved the cell bound, rather than the secreted protein. These data suggest an involvement of LM in the neuroblastoma differentiation process manifested both as an ability of LM to induce a morphological neuronal differentiation and as a selective control on LM metabolism during RA induced neuronal differentiation.
用视黄酸（RA）或外源性层粘连蛋白（LM）处理人类神经母细胞瘤细胞系SMS-KCNR，可诱导出类似的神经元形态分化模式。RA处理后，SMS-KCNR中LM的表达和合成增加，这涉及细胞结合的蛋白而非分泌蛋白。这些数据表明，LM参与神经母细胞瘤的分化过程，既表现为LM诱导神经元形态分化的能力，也表现为RA诱导神经元分化过程中对LM代谢的选择性调控。
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