Arfaoui Dalenda, Elloumi Héla, Salah Abderrazek, Ajmi Salem
Service d'hépato-gastroentérologie, CHU Sahloul, Sousse.
Tunis Med. 2005 Feb;83(2):83-6.
The aim of this study is to determine the factors associated with high risk of recurrence of Crohn disease.
During 12 years period from January 1987 till December 1999, 98 patients treated for Crohn's disease were included in this study. The risk of recurrence was studied using the Kaplan-Meier method. The possible predictive factors of recurrence were studied using the LOGRANK test.
During the follow-up period, 50 (66%) patients developed a recurrence of Crohn's disease. The factors associated with a high risk of recurrence of the diseases were female (p=0.03), long delay before the diagnosis of the disease (p=0.03) and the presence of extra-intestinal lesions (p=0.05). Concerning other factors such as the age, smoking, inflammatory syndrom and ano-perineal lesions, the study showed no relationship between these factors and the recurrence of the disease.
This study showed that the group of patients treated for Crohn's disease and who have predictive factors of recurrence should have prophylactic medical treatment to prevent recurrence of the disease.
本研究旨在确定与克罗恩病高复发风险相关的因素。
在1987年1月至1999年12月期间，本研究纳入了98例接受克罗恩病治疗的患者。采用Kaplan-Meier方法研究复发风险。使用LOGRANK检验研究复发的可能预测因素。
在随访期间，50例（66%）患者出现克罗恩病复发。与疾病高复发风险相关的因素为女性（p = 0.03）、疾病诊断前延迟时间长（p = 0.03）和存在肠外病变（p = 0.05）。关于年龄、吸烟、炎症综合征和肛门会阴病变等其他因素，研究表明这些因素与疾病复发之间无关联。
本研究表明，接受克罗恩病治疗且具有复发预测因素的患者组应接受预防性药物治疗以预防疾病复发。
Zotero 插件