肟加阿托品治疗对无阿托品酯酶兔梭曼中毒的疗效。

Efficacy of oxime plus atropine treatment against soman poisoning in the atropinesterase-free rabbit.

作者信息

Koplovitz I, Stewart J R

机构信息

United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010-5425.

出版信息

Drug Chem Toxicol. 1992;15(2):117-26. doi: 10.3109/01480549209032294.

DOI:10.3109/01480549209032294

PMID:1597126

Abstract

The oximes pralidoxime chloride (2-PAM), MMB4, and HI-6 were evaluated in combination with atropine as treatments against soman poisoning in atropinesterase-free rabbits. Animals were challenged i.m. with 2 x LD50 soman and treated at the onset of toxic signs with 50 mumols/kg of oxime and 5 or 13 mg/kg atropine. Survival and time to death were compared at 48 hours post-soman challenge. Survival rates in MMB4 and HI-6 treated animals were higher than in 2-PAM-treated animals. The increase in survival was significant at the 13 mg/kg dose of atropine. MMB4 and HI-6 also significantly delayed time to death after soman compared to 2-PAM. The results suggest that MMB4 and HI-6 have potential as useful oximes for treating soman poisoning.

摘要

对氯解磷定（2-PAM）、MMB4和HI-6这几种肟类药物与阿托品联合用药作为无阿托品酯酶家兔梭曼中毒治疗方法进行了评估。给动物肌肉注射2倍半数致死量的梭曼进行攻击，并在出现中毒症状时用50微摩尔/千克的肟类药物和5或13毫克/千克的阿托品进行治疗。在梭曼攻击后48小时比较存活情况和死亡时间。接受MMB4和HI-6治疗的动物的存活率高于接受2-PAM治疗的动物。在13毫克/千克剂量的阿托品治疗下，存活率的提高具有显著性。与2-PAM相比，MMB4和HI-6还显著延迟了梭曼中毒后的死亡时间。结果表明，MMB4和HI-6有潜力作为治疗梭曼中毒的有效肟类药物。