年轻亚洲女性的乳腺癌：生存情况研究。

Breast cancer in young Asian women: study on survival.

作者信息

Foo Chek Siang, Su David, Chong Chee Keong, Chng Hong Chee, Tay Khoon Hean, Low Sze Chuan, Tan Su Ming

机构信息

Department of General Surgery, Changi General Hospital, Singapore.

出版信息

ANZ J Surg. 2005 Jul;75(7):566-72. doi: 10.1111/j.1445-2197.2005.03431.x.

DOI:10.1111/j.1445-2197.2005.03431.x

PMID:15972049

Abstract

BACKGROUND

Breast cancer in young patients is often associated with a poorer prognosis, but there has been a paucity of published data in an Asian population.

METHODS

One hundred and six patients (12.6%) under the age of 40 years with breast cancer (group V) were compared with 737 patients with breast cancer aged 40 years or more (group W). Demographics, presentations, pathological profiles, treatment and survival measures were analysed.

RESULTS

Median tumour size was similar in both groups. Group V had more patients with grade 3 tumours and nodal involvement compared to group W (51.5% vs 38.1%, P = 0.012 and 52.5% vs 41.8%, P = 0.045). The mean Nottingham prognostic index (NPI) score was significantly higher in group V compared to group W (4.75 vs 4.26, P < 0.001). The incidences of chemotherapy and radiotherapy in group V were higher than group W (69.2% vs 35.2%, P < 0.001 and 41.1% vs 24.4%, P = 0.002). There were no differences in overall survival and disease-free survival (local recurrence).

CONCLUSION

Patients below 40 years with breast cancer have tumours with a poorer prognostic profile. However, this did not translate into a poorer overall survival, and this might be attributable to more aggressive adjuvant treatment of younger patients.

摘要

背景

年轻乳腺癌患者的预后通常较差，但亚洲人群中相关的公开数据较少。

方法

将106例年龄小于40岁的乳腺癌患者（V组）与737例年龄40岁及以上的乳腺癌患者（W组）进行比较。分析了人口统计学、临床表现、病理特征、治疗和生存指标。

结果

两组的肿瘤大小中位数相似。与W组相比，V组中3级肿瘤和淋巴结受累的患者更多（51.5%对38.1%，P = 0.012；52.5%对41.8%，P = 0.045）。V组的平均诺丁汉预后指数（NPI）得分显著高于W组（4.75对4.26，P < 0.001）。V组的化疗和放疗发生率高于W组（69.2%对35.2%，P < 0.001；41.1%对24.4%，P = 0.002）。总生存率和无病生存率（局部复发）无差异。