Asp Linnéa, Beraki Simret, Aronsson Fredrik, Rosvall Lina, Ogren Sven Ove, Kristensson Krister, Karlsson Håkan
Department of Neuroscience, Karolinska Institutet, Retzius v. 8, SE-171 77 Stockholm, Sweden.
Neuroreport. 2005 Jul 13;16(10):1111-5. doi: 10.1097/00001756-200507130-00016.
In this study, we tested the hypothesis that exposure to a maternal infection during fetal life can lead to the appearance of alterations in the brain later in life. C57BL/6 mice were infected intranasally with influenza A/WSN/33 virus on day 14 of gestation. The levels of transcripts encoding neuroleukin and fibroblast growth factor 5 were significantly elevated in the brains of the virus-exposed offspring at 90 and 280 days of age, but not at earlier time-points. For neuroleukin, this difference could also be observed at the protein level. Thus, a maternal influenza A virus infection can give rise to alterations in gene expression in the brain that become apparent only after a prepubertal latency period.
在本研究中，我们验证了这样一个假设：胎儿期暴露于母体感染可能导致其在日后生活中大脑出现改变。在妊娠第14天，将A/WSN/33甲型流感病毒经鼻内感染C57BL/6小鼠。在90日龄和280日龄时，暴露于病毒的后代大脑中编码神经白细胞素和成纤维细胞生长因子5的转录本水平显著升高，但在更早的时间点则未出现这种情况。对于神经白细胞素，在蛋白质水平也可观察到这种差异。因此，母体甲型流感病毒感染可导致大脑基因表达发生改变，而这种改变仅在青春期前的潜伏期后才会显现出来。
