Lankisch Tim O, Strassburg Christian P, Debray Dominique, Manns Michael P, Jacquemin Emmanuel
Department of Gastroenterlogy, Hannover Medical School, Hanover, Germany.
J Pediatr. 2005 Jun;146(6):839-42. doi: 10.1016/j.jpeds.2005.01.050.
Autoimmune regulator gene mutations were identified in 3 children with type 2 autoimmune hepatitis and extrahepatic immune diseases, including 1 child with immune hepatitis recurrence after liver transplantation. These findings suggest that autoimmune regulator gene variants might predispose children to systemic autoimmune disease, a recurrence of immune disease, or both.
在3例2型自身免疫性肝炎合并肝外免疫疾病的儿童中发现了自身免疫调节基因的突变，其中1例在肝移植后出现免疫性肝炎复发。这些发现表明，自身免疫调节基因变异可能使儿童易患全身性自身免疫性疾病、免疫性疾病复发或两者兼而有之。
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