I/II期外阴癌患者浅表腹股沟淋巴结清扫术阴性后的结局

Outcomes of Stage I/II vulvar cancer patients after negative superficial inguinal lymphadenectomy.

作者信息

Kirby Tyler O, Rocconi Rodney P, Numnum T Michael, Kendrick James E, Wright Jason, Fowler Wiley, Mutch David G, Bhoola Snehal M, Huh Warner K, Straughn J Michael

机构信息

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, OHB 538, 619 19th Street South, Birmingham, AL 35249-7333, USA.

出版信息

Gynecol Oncol. 2005 Aug;98(2):309-12. doi: 10.1016/j.ygyno.2005.05.011.

DOI:10.1016/j.ygyno.2005.05.011

PMID:15975642

Abstract

OBJECTIVES

To investigate the patterns of recurrence associated with superficial inguinal lymphadenectomy (SupIL) and vulvectomy for patients with Stage I/II vulvar cancer.

METHODS

A retrospective chart review identified patients from 1990-2001 with Stage I/II vulvar cancer that underwent SupIL and vulvectomy. Survival was analyzed using the Kaplan-Meier method with Fisher Exact and Chi-square tests for comparisons between groups.

RESULTS

65 patients with Stage I/II vulvar cancer with a pathologically negative SupIL were identified (30 Stage I, 35 Stage II). Three patients recurred in the inguinal region, (4.6%) and 11 patients (16.9%) recurred on the vulva. Two of the 11 patients died of disease, six patients are alive without evidence of disease after additional therapy. Five-year disease-free survival and overall survival were 66% and 97%, respectively. Risk of recurrence was not associated with smoking status, stage, or margin status.

CONCLUSIONS

SupIL and vulvectomy for Stage I/II vulvar cancer have a low recurrence rate in the inguinal region when nodes are negative. The local recurrence rate (17%) is acceptable, and overall survival is good using this conservative approach.

摘要

目的

探讨I/II期外阴癌患者行腹股沟浅淋巴结清扫术（SupIL）及外阴切除术的复发模式。

方法

通过回顾性病历审查，确定了1990年至2001年间接受SupIL及外阴切除术的I/II期外阴癌患者。采用Kaplan-Meier方法分析生存率，并使用Fisher精确检验和卡方检验进行组间比较。

结果

确定了65例I/II期外阴癌患者，其腹股沟浅淋巴结清扫术病理结果为阴性（I期30例，II期35例）。3例患者腹股沟区复发（4.6%），11例患者（16.9%）外阴复发。11例患者中有2例死于疾病，6例患者在接受额外治疗后无疾病证据存活。5年无病生存率和总生存率分别为66%和97%。复发风险与吸烟状况、分期或切缘状况无关。