Salazar-Gonzalez Rosa Maria, McSorley Stephen J
Department of Medicine, Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030-1319, USA.
Immunol Lett. 2005 Nov 15;101(2):117-22. doi: 10.1016/j.imlet.2005.05.004. Epub 2005 Jun 6.
Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.
细菌鞭毛蛋白是许多微生物病原体用于运动的重要组成部分。这些蛋白质也是宿主在感染和自身免疫性疾病期间固有免疫和适应性免疫反应的靶点。鞭毛蛋白与Toll样受体5（TLR-5）相互作用，并在体内引发促炎反应和激活宿主树突状细胞。此外，在沙门氏菌感染期间，鞭毛蛋白可被抗体和CD4 T细胞识别。在此，我们综述了对鞭毛蛋白与宿主免疫系统相互作用理解的最新进展。
