Henquet Cécile, Murray Robin, Linszen Don, van Os Jim
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, European Graduate School of Neuroscience, Maastricht University, Maastricht, the Netherlands.
Schizophr Bull. 2005 Jul;31(3):608-12. doi: 10.1093/schbul/sbi027. Epub 2005 Jun 23.
Cannabis use is associated with poor outcome in existing schizophrenia and may precipitate psychosis in individuals with preexisting liability. To investigate the overall effect size and consistency of the association between cannabis and psychosis, a meta-analysis from prospective studies was carried out. The pooled odds ratio was 2.1 (95% CI: 1.7-2.5) and could not be explained by confounding or reverse causality. Evidence suggests that cannabis is a component cause in the development and prognosis of psychosis, in which mechanisms of gene-environment interaction are most likely to explain this association. Potential new methods to directly link genetic liability to the effects of cannabis are discussed.
使用大麻与现有精神分裂症的不良预后相关，并且可能使具有易感性的个体引发精神病。为了研究大麻与精神病之间关联的总体效应大小和一致性，对前瞻性研究进行了一项荟萃分析。合并优势比为2.1（95%置信区间：1.7 - 2.5），且无法用混杂因素或反向因果关系来解释。有证据表明，大麻是精神病发生和预后的一个成因，其中基因 - 环境相互作用机制最有可能解释这种关联。文中还讨论了将遗传易感性与大麻效应直接联系起来的潜在新方法。
