Tziakas Dimitrios N, Chalikias Georgios K, Hatzinikolaou Eleni I, Stakos Dimitrios A, Tentes Ioannis K, Kortsaris Alexandros, Hatseras Dimitrios I, Kaski Juan Carlos
University Cardiology Clinic, Democritus University of Thrace, Alexandroupolis, Greece.
Am J Cardiol. 2005 Jul 1;96(1):31-4. doi: 10.1016/j.amjcard.2005.02.039.
N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a predictor of left ventricular remodeling. Matrix metalloproteinases (MMPs) contribute to collagen breakdown that is associated with ventricular remodeling after acute myocardial infarction (AMI). We assessed the association between circulating levels of NT-pro-BNP, MMP-2, and MMP-9 and their inhibitor (tissue inhibitor of metalloproteinase-1) early (24 and 72 hours) and late (7 and 30 days) after AMI in 108 patients who had ST-elevation AMI (90 men; mean age 60 years). Serum MMP-2 levels measured 24 and 72 hours after AMI were inversely associated with NT-pro-BNP levels, whereas MMP-9 serum levels were positively related. During late-stage remodeling after AMI, circulating concentrations of tissue inhibitor of metalloproteinase-1 were independently associated with NT-pro-BNP levels 7 and 30 days after AMI. This study shows that, in patients who have ST-elevation AMI, circulating levels of NT-pro-BNP are associated with MMPs in a species-specific and time-dependent manner.
N 末端前 B 型利钠肽（NT-pro-BNP）是左心室重构的一个预测指标。基质金属蛋白酶（MMPs）促使胶原蛋白分解，这与急性心肌梗死（AMI）后的心室重构相关。我们评估了 108 例 ST 段抬高型 AMI 患者（90 名男性；平均年龄 60 岁）在 AMI 早期（24 小时和 72 小时）及晚期（7 天和 30 天）时循环血中 NT-pro-BNP、MMP-2、MMP-9 及其抑制剂（金属蛋白酶组织抑制剂-1）水平之间的关联。AMI 后 24 小时和 72 小时测得的血清 MMP-2 水平与 NT-pro-BNP 水平呈负相关，而 MMP-9 血清水平则呈正相关。在 AMI 后期重构过程中，金属蛋白酶组织抑制剂-1 的循环浓度与 AMI 后 7 天和 30 天的 NT-pro-BNP 水平独立相关。本研究表明，在 ST 段抬高型 AMI 患者中，循环血中 NT-pro-BNP 水平与 MMPs 以种属特异性和时间依赖性方式相关。
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