[多中心性网状组织细胞增生症：一例全身性疾病的报告]

[Multicentric reticulohistiocytosis: report of a case with systemic disease].

作者信息

Stock Nathalie, Saikali Stephan, Chevrant-Breton Jacqueline, Leroy Jean-Pierre, Le Gall François

机构信息

Département d'Anatomie Pathologique, CHU Pontchaillou, 2 rue H. Le Guillou, 35033 Rennes 9.

出版信息

Ann Pathol. 2005 Feb;25(1):50-3. doi: 10.1016/s0242-6498(05)80099-9.

DOI:10.1016/s0242-6498(05)80099-9

PMID:15981932

Abstract

Multicentric reticulohistiocytosis (RHM) is a rare non Langherhans cell histiocytosis with skin and joint involvment. Nearly all organs can be involved. Association with cancer occurs in about 25% of cases. Association with auto-immune diseases has also been recorded. Microscopic examination shows a histiocytic nodular infiltrate made of giant cells with ground-glass appearance and PAS positive cytoplasm. Immunostaining shows cell positivity for CD68 and negativity for CD1a and S100 protein. No Birbeck granules are found at ultrastructural examination.

摘要

多中心性网状组织细胞增多症（RHM）是一种罕见的非朗格汉斯细胞组织细胞增多症，可累及皮肤和关节。几乎所有器官都可能受累。约25%的病例与癌症有关。也有与自身免疫性疾病相关的记录。显微镜检查显示由具有毛玻璃样外观和PAS阳性细胞质的巨细胞组成的组织细胞结节性浸润。免疫染色显示细胞对CD68呈阳性，对CD1a和S100蛋白呈阴性。超微结构检查未发现Birbeck颗粒。