Song Jong-Suk, Kwon Sangwon, Shyn Kyung-Hwan
Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Korean J Ophthalmol. 2005 Jun;19(2):156-9. doi: 10.3341/kjo.2005.19.2.156.
To describe a case of unilateral comeal keloid and present the clinical and histopathological findings and the management.
A 23-year-old Asian male patient was examined for a white spot on the left cornea that had been present since birth. On biomicroscopic examination, a well-demarcated vascularized comeal mass was found located nasal to the center. The pupil was displaced superiorly, and gonioscopic examination showed peripheral iridocomeal adhesion at 12 o'clock. The patient underwent penetrating keratoplasty.
Histopathologic study showed a variously thickened epithelial layer, an absence of Bowman's layer, subepithelial fibrovascular hyperplasia, and an absence of dermal elements. These histopathologic findings suggested a congenital comeal keloid. The central graft comea remained clear at 18 months after surgery and the patient was satisfied with the result.
Penetrating keratoplasty may be an effective surgical option for congenital keloids in young adult patients.
描述一例单侧角膜瘢痕疙瘩病例，并呈现临床和组织病理学检查结果以及治疗情况。
对一名23岁的亚洲男性患者进行检查，其左眼角膜上有一个自出生就存在的白斑。在生物显微镜检查中，发现一个界限清晰的血管化角膜肿物位于角膜中央鼻侧。瞳孔向上移位，前房角镜检查显示12点处有周边虹膜角膜粘连。该患者接受了穿透性角膜移植术。
组织病理学研究显示上皮层不同程度增厚，Bowman层缺失，上皮下纤维血管增生，且无真皮成分。这些组织病理学表现提示为先天性角膜瘢痕疙瘩。术后18个月中央移植角膜保持清晰，患者对结果满意。
穿透性角膜移植术可能是年轻成年患者先天性瘢痕疙瘩的一种有效手术选择。
