α-螺旋促肾上腺皮质激素释放激素对人类睡眠-内分泌活动具有促肾上腺皮质激素释放激素激动作用。

Alpha-helical CRH exerts CRH agonistic effects on sleep-endocrine activity in humans.

作者信息

Held Katja, Antonijevic Irina, Murck Harald, Künzel Heike, Steiger Axel

机构信息

Max-Planck-Institute of Psychiatry, Department of Psychiatry, Munich, Germany.

出版信息

Neuropsychobiology. 2005;52(2):62-7. doi: 10.1159/000086606. Epub 2005 Jun 29.

DOI:10.1159/000086606

PMID:15990457

Abstract

CRH is known to enhance wakefulness and to reduce SWS. In addition, some but not all, studies suggest that CRH promotes REM sleep. Alpha-helical CRH exerts CRH-antagonistic effects in various studies. We studied its effect on sleep EEG and nocturnal secretion of ACTH, cortisol, GH (n = 7) in young normal male subjects. After administering the substance cortisol and ACTH levels were enhanced during the total night compared to placebo. We found an increase of the time spent awake for the first half. ACTH (2nd half of the night) and cortisol (total night and 1st half of the night) increased. The results of the present study correspond to a mixture of agonistic and antagonistic effects of alpha-helical CRH.

摘要

已知促肾上腺皮质激素释放激素（CRH）可增强清醒状态并减少慢波睡眠（SWS）。此外，一些（但并非全部）研究表明CRH可促进快速眼动睡眠（REM睡眠）。在各种研究中，α-螺旋CRH发挥着CRH拮抗作用。我们研究了其对年轻正常男性受试者睡眠脑电图以及促肾上腺皮质激素（ACTH）、皮质醇、生长激素（GH）夜间分泌（n = 7）的影响。与安慰剂相比，给予该物质后，皮质醇和ACTH水平在整个夜间均升高。我们发现前半夜清醒时间增加。ACTH（后半夜）和皮质醇（整个夜间和前半夜）升高。本研究结果对应于α-螺旋CRH的激动和拮抗作用的混合效应。