急性髓系白血病中的多重逆转录聚合酶链反应筛查可检测出具有预后意义但细胞遗传学未揭示的异常情况。
Multiplex reverse transcription polymerase chain reaction screening in acute myeloid leukemia detects cytogenetically unrevealed abnormalities of prognostic significance.
作者信息
Hutchings Hoffmann Marianne, Wirenfeldt Klausen Tobias, Hasle Henrik, Schmiegelow Kjeld, Brondum-Nielsen Karen, Johnsen Hans Erik
出版信息
Haematologica. 2005 Jul;90(7):984-6.
PMID:15996940
Abstract
A commercial multiplex reverse transcription polymerase chain reaction screening assay, covering 28 leukemic fusion transcripts, was applied in 143 samples obtained from patients with acute myeloid leukemia at primary diagnosis. In five patients, a cytogenetically unrevealed fusion gene of prognostic importance was detected, while the assay failed to detect one case of t(15;17).
摘要
一种涵盖28种白血病融合转录本的商业多重逆转录聚合酶链反应筛查检测方法，应用于143例初诊急性髓系白血病患者的样本。在5例患者中，检测到一种细胞遗传学未揭示的具有预后重要性的融合基因，而该检测方法未能检测到1例t(15;17)病例。
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