Abbasnejad M, Jonaidi H, Denbow D M, Pour Rahimi A M
Department of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman, 76169-133 Kerman, Iran.
Physiol Behav. 2005 Jul 21;85(4):383-6. doi: 10.1016/j.physbeh.2005.03.016.
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the opioid receptor-like receptor or nociceptin receptor (NOP), has been shown to induce feeding, locomotion, anti-stress and anxiolytic effects in rodents after central nervous system injection. In this study, the effect of intracerebroventricular (icv) injection of N/OFQ on feeding and locomotion behavior was evaluated in male broiler-type chickens. The icv injection of N/OFQ caused a moderate but significant increase in feed intake similar to the classical opioid peptides in rats. It also increased feed pecking frequency and feeding time 1 h after injection. Stepping, wing flapping and preening were not affected by N/OFQ. These results suggest that N/OFQ can act within the central nervous system of chickens to increase feed intake.
痛敏肽/孤啡肽FQ（N/OFQ）是阿片样受体样受体或痛敏肽受体（NOP）的内源性配体，已证明在中枢神经系统注射后可在啮齿动物中诱导进食、运动、抗应激和抗焦虑作用。在本研究中，评估了脑室内（icv）注射N/OFQ对雄性肉仔鸡进食和运动行为的影响。与大鼠中的经典阿片肽类似，icv注射N/OFQ导致采食量适度但显著增加。它还增加了注射后1小时的啄食频率和进食时间。踏步、扑翼和梳理行为不受N/OFQ影响。这些结果表明，N/OFQ可在鸡的中枢神经系统内发挥作用以增加采食量。
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