Rizzi Marta, Gerloni Mara, Srivastava Anand S, Wheeler Matthew C, Schuler Kilian, Carrier Ewa, Zanetti Maurizio
The Laboratory of Immunology, Department of Medicine and Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0837, USA.
Vaccine. 2005 Jul 21;23(33):4273-82. doi: 10.1016/j.vaccine.2004.11.046.
The function and plasticity of the developing immune system during embryonic life has been central to immunological thinking for half a century. A classical view is that antigen encountered during fetal life induces a state of acquired immunological tolerance. However, the ability to develop T cell immune responses during the perinatal period would be of great importance against intracellular pathogens. Recent experiments have challenged this notion and shown that neonatal tolerance can be circumvented by extrinsic immunological manipulations. Here, we used DNA immunization targeted at B lymphocytes to induce a CD4 T cell response that could be measured 2 weeks after birth. We conclude that T cell immunity can be programmed in utero by manipulating the parameters of the immune response in the fetal environment. Furthermore, our data suggest that under appropriate conditions the fetal immune system can be programmed to immunity.
半个世纪以来，胚胎期发育中的免疫系统的功能和可塑性一直是免疫学思考的核心。传统观点认为，胎儿期接触的抗原会诱导获得性免疫耐受状态。然而，围产期产生T细胞免疫反应的能力对于抵抗细胞内病原体至关重要。最近的实验对这一观点提出了挑战，并表明通过外在的免疫操作可以规避新生儿耐受。在此，我们采用针对B淋巴细胞的DNA免疫来诱导出生后2周即可检测到的CD4 T细胞反应。我们得出结论，通过操纵胎儿环境中的免疫反应参数，可以在子宫内对T细胞免疫进行编程。此外，我们的数据表明，在适当条件下，胎儿免疫系统可以被编程为免疫状态。
