易卒中型自发性高血压大鼠对缓激肽的血管舒张反应增强。

Enhanced vasodilatory responses to bradykinin in stroke-prone spontaneously hypertensive rats.

作者信息

Stier C T, Selig N, Itskovitz H D

机构信息

Department of Pharmacology, New York Medical College, Valhalla 10595.

出版信息

Eur J Pharmacol. 1992 Jan 14;210(2):217-9. doi: 10.1016/0014-2999(92)90675-t.

DOI:10.1016/0014-2999(92)90675-t

PMID:1601060

Abstract

Vasodilatory responses to bradykinin (BK) and acetylcholine (ACh) were compared in phenylephrine preconstricted perfused kidneys from 30-week-old male stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). Responses to ACh did not differ between kidneys from SHRSP and WHY. BK-induced dilatation was greater in kidneys from SHRSP relative to WHY and was not affected by indomethacin or captopril. These results indicate that renal vasodilatory responsiveness to bradykinin is enhanced in SHRSP with established hypertension.

摘要

在30周龄的雄性易卒中型自发性高血压大鼠（SHRSP）和正常血压的Wistar-Kyoto大鼠（WKY）的去氧肾上腺素预收缩的灌注肾中，比较了对缓激肽（BK）和乙酰胆碱（ACh）的血管舒张反应。SHRSP和WKY的肾对ACh的反应没有差异。相对于WKY，SHRSP的肾中BK诱导的扩张更大，且不受吲哚美辛或卡托普利的影响。这些结果表明，患有已确诊高血压的SHRSP中，肾对缓激肽的血管舒张反应性增强。