Engels F K, Sparreboom A, Mathot R A A, Verweij J
Department of Medical Oncology, Erasmus MC - Daniel den Hoed Cancer Center Rotterdam, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands.
Br J Cancer. 2005 Jul 25;93(2):173-7. doi: 10.1038/sj.bjc.6602698.
Since the introduction of docetaxel, research has focused on various approaches to overcome treatment limitations and improve outcome. This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes.
自从多西他赛问世以来,研究一直集中在克服治疗局限性和改善治疗效果的各种方法上。本综述讨论了优化治疗的药理学尝试,包括减少个体间药代动力学和药效学变异性、优化给药方案、给药途径、逆转耐药性以及开发结构相关的第二代紫杉烷类药物。