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[2003年比亚韦斯托克地区住院儿童(无论有无腹泻)粪便中白色念珠菌的患病率]

[Prevalence of Candida albicans in stool of hospitalized children in 2003 with or without diarrhea from the Bialystok region].

作者信息

Rozkiewicz Dorota, Daniluk Tamara, Sciepuk Małgorzata, Kurzqtkowska Bozena, Ołdak Elzbieta, Zaremba Maria Lucyna

机构信息

Klinik Obserwacyjno-Zakazna Dzieci Akademii Medycznej w Białymstoku.

出版信息

Przegl Epidemiol. 2005;59(1):43-51.

Abstract

Candida species, predominantly Candida albicans strains, are part of the normal flora of gastrointestinal tract, but some authors suggest that faecal candida may cause diarrhoea. The aim of this study was to determine the prevalence of faecal Candida spp. isolates in 345 children with diarrhoea and 161 with other diseases, hospitalized in 2003. Overall 506 faecal specimens obtained before treatment and 98 after treatment of children for yeasts using routine culture method were examined. A total of 131 (101 before and 30 after treatment) strains isolated were identified as Candida albicans. Only 2 strains belonged to other species of Candida (C. parapsilosis and C. krusei). The sensitivity of Candida spp. strains to chemotherapeutic was also estimated. All strains of C. albicans were sensitive to nystatin. Incidence of faecal strains of C. albicans in children with acute diarrhoea (19,4%) and children with other disease (21,1%) was comparable (p>0,05). Candida albicans yeasts caused diarrhoea in small percent of studied children. Only in 2 (0,6%) children C. albicans as aetiological agent of diarrhoea was found. In 16 (16,3%) cases secondary fungal infections were acquired during hospitalization children (4 children with fungal diarrhoea). Resolution of diarrhoea caused by C. albicans in 6 children after treatment with nystatin was observed.

摘要

念珠菌属,主要是白色念珠菌菌株,是胃肠道正常菌群的一部分,但一些作者认为粪便中的念珠菌可能会导致腹泻。本研究的目的是确定2003年住院的345名腹泻儿童和161名患有其他疾病的儿童中粪便念珠菌属分离株的患病率。使用常规培养方法对506份在儿童治疗前获取的粪便标本以及98份治疗后用于检测酵母菌的粪便标本进行了检查。总共分离出131株菌株(治疗前101株,治疗后30株),鉴定为白色念珠菌。仅2株属于其他念珠菌属(近平滑念珠菌和克柔念珠菌)。还评估了念珠菌属菌株对化疗药物的敏感性。所有白色念珠菌菌株对制霉菌素敏感。急性腹泻儿童(19.4%)和患有其他疾病的儿童(21.1%)中白色念珠菌粪便菌株的发生率相当(p>0.05)。白色念珠菌酵母菌在一小部分研究儿童中导致腹泻。仅在2名(0.6%)儿童中发现白色念珠菌是腹泻的病原体。在16例(16.3%)病例中,住院儿童发生了继发性真菌感染(4名儿童患有真菌性腹泻)。观察到6名儿童在使用制霉菌素治疗后由白色念珠菌引起的腹泻得到缓解。

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