不明原因复发性流产女性的遗传性血栓形成风险因素。
Genetic prothrombotic risk factors in women with unexplained pregnancy loss.
作者信息
Sottilotta Gianluca, Oriana Vincenzo, Latella Caterina, Luise Francesca, Piromalli Angela, Ramirez Francesca, Mammì Corrado, Santoro Rita, Iannaccaro Piergiorgio, Muleo Gaetano, Lombardo Vincenzo Trapani
机构信息
Centro Emofilia-Servizio Emostasi e Trombosi, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy.
出版信息
Thromb Res. 2006;117(6):681-4. doi: 10.1016/j.thromres.2005.06.005. Epub 2005 Jul 12.
INTRODUCTION
Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FII G20210A in women with adverse pregnancy outcome, compared to the prevalence of the same mutations in our health control group.
MATERIALS AND METHODS
102 consecutive women with unexplained pregnancy loss (55 with history of RPL, and 47 with history of stillbirth) were studied for hereditary thrombophilia. The health control group consisted of 217 healthy women from the general population.
RESULTS AND CONCLUSIONS
Of the 55 women with recurrent abortions, we found the same prevalence for the FVL and the FII G20210A(9.1%, 5 pts). (p=NS compared to control group). Of the 47 women with stillbirth, 11 (23.4%) had the FVL and 9 (19.1%) had the FII G20210A(p<0.0005 for both mutations). In our experience the prevalence of FVL and the FII G20210Amutations was significantly higher in women with unexplained stillbirth, instead the prevalence of genetic thrombophilia was high but not statistically significant in women with recurrent pregnancy loss.
引言
遗传性易栓症与不明原因的复发性流产（RPL）和死产有关。这种血栓形成倾向可表现为胎盘血栓形成病变，并可能导致流产和死产。我们病例对照研究的目的是调查不良妊娠结局女性中因子V Leiden（FVL）和凝血因子II G20210A的患病率，并与我们健康对照组中相同突变的患病率进行比较。
材料与方法
对102例连续的不明原因流产女性（55例有复发性流产史，47例有死产史）进行遗传性易栓症研究。健康对照组由217名来自普通人群的健康女性组成。
结果与结论
在55例复发性流产女性中，我们发现FVL和凝血因子II G20210A的患病率相同（9.1%，5例）。（与对照组相比，p=无显著性差异）。在47例死产女性中，11例（23.4%）有FVL，9例（19.1%）有凝血因子II G20210A（两种突变的p均<0.0005）。根据我们的经验，不明原因死产女性中FVL和凝血因子II G20210A突变的患病率显著更高，而复发性流产女性中遗传性易栓症的患病率虽高但无统计学意义。
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