Bhaskaram P, Hemalatha P, Rao K V
National Institute of Nutrition, Indian Council of Medical Research, Jamia Osmania, Hyderabad.
Indian Pediatr. 1992 Jan;29(1):39-44.
The efficacy of BCG vaccination is still a subject of controversy. In the present study the protective role of BCG vaccination, the influence of nutritional status and justification for revaccination in children were investigated. Of the 504 preschool children suffering from tuberculosis who were registered for the study, 345 children did not receive BCG vaccine while the others had it during early infancy. Vaccinated children showed a significantly greater tendency to localise the tubercular lesions while most of the unvaccinated children suffered from progressive forms of the infection. Vaccination had similar effects even when there was associated malnutrition. Age did not seem to influence the severity of the disease in unvaccinated children while older children (greater than 3 yrs) had a greater tendency to localise the lesion in the vaccinated group. These data do not support the proposal of administering a booster dose of BCG to children who were vaccinated during early infancy.
卡介苗接种的效果仍是一个有争议的话题。在本研究中，调查了卡介苗接种的保护作用、营养状况的影响以及儿童复种的理由。在登记参加该研究的504名患结核病的学龄前儿童中，345名儿童未接种卡介苗，其余儿童在婴儿早期接种过。接种疫苗的儿童结核病变局限化的倾向明显更大，而大多数未接种疫苗的儿童患有进展性感染。即使存在合并营养不良，接种疫苗也有类似效果。年龄似乎不影响未接种疫苗儿童疾病的严重程度，而在接种疫苗组中，年龄较大的儿童（大于3岁）结核病变局限化的倾向更大。这些数据不支持对婴儿早期接种过疫苗的儿童给予卡介苗加强剂量的提议。
