通过连续的范鲁森反应/关环复分解反应合成稠合双环咪唑。
Synthesis of fused bicyclic imidazoles by sequential van Leusen/ring-closing metathesis reactions.
作者信息
Gracias Vijaya, Gasiecki Alan F, Djuric Stevan W
机构信息
Scaffold-Oriented Synthesis, Medicinal Chemistry Technologies, Abbott Laboratories, R4CP, AP10, Illinois 60064-6099, USA.
出版信息
Org Lett. 2005 Jul 21;7(15):3183-6. doi: 10.1021/ol050852+.
PMID:16018616
Abstract
[reaction: see text]. A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.
摘要
[反应：见正文]。报道了一种新策略，该策略依次采用范鲁森三组分反应和闭环复分解反应来构建稠合双环咪唑环。该两步反应序列以简便的方式从简单的起始原料高效地生成了具有显著分子复杂性的化合物，产率优异。
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