生殖细胞肿瘤：近期数据更新及Ⅰ期和转移性疾病现行治疗方案综述

Germ cell tumors: an update of recent data and review of active protocols in stage I and metastatic disease.

作者信息

Hahn Noah M, Sweeney Christopher J

机构信息

Department of Medicine, Hematology and Oncology, Indiana University, Indianapolis, IN 46202, USA.

出版信息

Urol Oncol. 2005 Jul-Aug;23(4):293-302. doi: 10.1016/j.urolonc.2005.05.008.

DOI:10.1016/j.urolonc.2005.05.008

PMID:16018947

Abstract

Germ cell tumors are highly curable malignancies even when metastatic. Investigations currently focus on curtailing toxicity in low-risk patients and improving cure rates in poor-risk individuals. Reduced dose radiation schedules and short-course chemotherapy regimens have been evaluated in stage I disease. In metastatic disease, several new nonplatinum agents offer promise for patients with poor risk or relapsed disease. In addition, high-dose chemotherapy regimens with autologous stem cell transplant provide potential for further improvements in survival. This review will highlight recent developments and currently active clinical trials pertinent to the treatment of patients with germ cell tumors.

摘要

生殖细胞肿瘤即使发生转移也是高度可治愈的恶性肿瘤。目前的研究重点是减少低风险患者的毒性，并提高高风险患者的治愈率。已对I期疾病的低剂量放疗方案和短程化疗方案进行了评估。在转移性疾病中，几种新的非铂类药物为高风险或复发疾病的患者带来了希望。此外，自体干细胞移植的高剂量化疗方案为进一步提高生存率提供了潜力。本综述将重点介绍与生殖细胞肿瘤患者治疗相关的最新进展和当前正在进行的临床试验。