Okabe Seiichi, Miyazawa Keisuke, Iguchi Tomotaka, Sumi Masahiko, Takaku Tomoiku, Ito Yoshikazu, Kimura Yukihiko, Serizawa Hiromi, Mukai Kiyoshi, Ohyashiki Kazuma
First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
Leuk Lymphoma. 2005 Apr;46(4):599-602. doi: 10.1080/10428190400029809.
Myelofibrosis is usually observed in myeloproliferative disorders, such as chronic myeloid leukemia. However, there are only a few reports showing an association between T-cell lymphoma and myelofibrosis. We report a case of peripheral T-cell lymphoma, unspecified (diffuse large cell) type, involving the bone marrow that was associated with severe myelofibrosis. In the present case, the plasma concentration of transforming growth factor-beta1 (TGF-beta1) was increased to 8.95 ng/ml (normal range: 1.56-3.24 ng/ml). No lymphadenopathy or skin lesions were observed during the entire clinical course. Although the mechanism of secondary myelofibrosis is still unclear, elevated plasma TGF-beta1 might be involved in the pathogenesis of bone marrow fibrosis in the present case.
骨髓纤维化通常见于骨髓增殖性疾病，如慢性髓性白血病。然而，仅有少数报告显示T细胞淋巴瘤与骨髓纤维化之间存在关联。我们报告一例未特定类型（弥漫大细胞型）的外周T细胞淋巴瘤累及骨髓并伴有严重骨髓纤维化的病例。在本病例中，转化生长因子β1（TGF-β1）的血浆浓度升高至8.95 ng/ml（正常范围：1.56 - 3.24 ng/ml）。在整个临床过程中未观察到淋巴结病或皮肤病变。虽然继发性骨髓纤维化的机制仍不清楚，但血浆TGF-β1升高可能参与了本病例骨髓纤维化的发病机制。
