Arfsten D P, Bekkedal M, Wilfong E R, Rossi J, Grasman K A, Healey L B, Rutkiewicz J M, Johnson E W, Thitoff A R, Jung A E, Lohrke S R, Schaeffer D J, Still K R
Naval Health Research Center Detachment, Environmental Health Effects Laboratory, Wright-Patterson AFB, Ohio, USA.
J Toxicol Environ Health A. 2005;68(11-12):967-97. doi: 10.1080/15287390590912603.
In 2001, the Naval Health Research Center Toxicology Detachment was funded by the U.S. Army Medical Research Acquisition Activity (USAMRAA) to conduct a study of the effects of surgically implanted depleted uranium (DU) pellets on adult rat reproductive success and development across two successive generations. This article presents some of the findings for the group of offspring from adult rats mated at 30 d post surgical implantation of DU pellets. Adult male and female Sprague-Dawley rats (P1 generation) were surgically implanted with 0, 4, 8, or 12 DU pellets (1 x 2 mm). The P1 generation was then cross-mated at 30 d post surgical implantation. Urine collected from P1 animals at 27 d post surgical implantation showed that DU was excreted in the urine of DU-implanted animals in a dose-dependent manner. DU surgical implantation did not have a negative impact on P1 reproductive success, survival, or body weight gain through post surgical implantation d 90. There were no statistically significant differences in F1 birth weight, survival, and litter size at postnatal day (PND) 0, 5, and 20. No gross physical abnormalities identified in the offspring were attributable to neonatal DU exposure. A series of neurodevelopment and immune function assessments were also conducted on F1 offspring. No group differences were observed that were related to parental DU exposure. Studies are ongoing on the impact of leaving DU embedded in soft tissue for 120 d on rat reproduction and subsequent offspring survival and development.
2001年，海军卫生研究中心毒理学分队获得美国陆军医学研究采购活动（USAMRAA）的资助，开展一项关于手术植入贫铀（DU）颗粒对成年大鼠两代连续生殖成功率和发育影响的研究。本文介绍了在手术植入DU颗粒后30天交配的成年大鼠所产后代组的一些研究结果。成年雄性和雌性Sprague-Dawley大鼠（P1代）被手术植入0、4、8或12颗DU颗粒（1×2毫米）。然后在手术植入后30天对P1代进行杂交交配。在手术植入后27天从P1动物收集的尿液显示，植入DU的动物尿液中DU的排泄呈剂量依赖性。手术植入DU对P1代生殖成功率、存活率或手术植入后90天内的体重增加没有负面影响。在出生后第0、5和20天，F1代的出生体重、存活率和窝仔数没有统计学上的显著差异。在后代中未发现可归因于新生儿接触DU的明显身体异常。还对F1代后代进行了一系列神经发育和免疫功能评估。未观察到与亲代接触DU相关的组间差异。关于DU在软组织中嵌入120天对大鼠繁殖以及随后后代存活率和发育的影响的研究正在进行中。
