Gushue David L, Houck Jeff, Lerner Amy L
Department of Biomedical Engineering, 215 Hopeman Hall, University of Rochester, River Campus Box 270168, Rochester, NY, USA.
J Orthop Res. 2005 Jul;23(4):735-42. doi: 10.1016/j.orthres.2005.01.005. Epub 2005 Mar 2.
Although the rabbit hindlimb has been commonly used as an experimental animal model for studies of osteoarthritis, bone growth and fracture healing, the in vivo biomechanics of the rabbit knee joint have not been quantified. The purpose of this study was to investigate the kinematic and kinetic patterns during hopping of the adult rabbit, and to develop a model to estimate the joint contact force distribution between the tibial plateaus. Force platform data and three-dimensional motion analysis using infrared markers mounted on intracortical bone pins were combined to calculate the knee and ankle joint intersegmental forces and moments. A statically determinate model was developed to predict muscle, ligament and tibiofemoral joint contact forces during the stance phase of hopping. Variations in hindlimb kinematics permitted the identification of two landing patterns, that could be distinguished by variations in the magnitude of the external knee abduction moment. During hopping, the prevalence of an external abduction moment led to the prediction of higher joint contact forces passing through the lateral compartment as compared to the medial compartment of the knee joint. These results represent critical data on the in vivo biomechanics of the rabbit knee joint, which allow for comparisons to both other experimental animal models and the human knee, and may provide further insight into the relationships between mechanical loading, osteoarthritis, bone growth, and fracture healing.
尽管兔后肢常被用作骨关节炎、骨生长和骨折愈合研究的实验动物模型，但兔膝关节的体内生物力学尚未得到量化。本研究的目的是研究成年兔跳跃过程中的运动学和动力学模式，并建立一个模型来估计胫骨平台之间的关节接触力分布。将力平台数据与使用安装在皮质内骨钉上的红外标记进行的三维运动分析相结合，以计算膝关节和踝关节的节段间力和力矩。开发了一个静定模型来预测跳跃站立阶段的肌肉、韧带和胫股关节接触力。后肢运动学的变化使得能够识别两种着陆模式，这两种模式可以通过外部膝关节外展力矩大小的变化来区分。在跳跃过程中，与膝关节内侧相比，外部外展力矩的普遍存在导致预测通过外侧间室的关节接触力更高。这些结果代表了兔膝关节体内生物力学的关键数据，可用于与其他实验动物模型和人类膝关节进行比较，并可能进一步深入了解机械负荷、骨关节炎、骨生长和骨折愈合之间的关系。
