在由二肉豆蔻酰磷脂酰胆碱/双子表面活性剂形成的脂质体中包含光敏剂：复合物的物理化学和生物学特性之间的相关性。

Inclusion of a photosensitizer in liposomes formed by DMPC/gemini surfactant: correlation between physicochemical and biological features of the complexes.

作者信息

Bombelli Cecilia, Caracciolo Giulio, Di Profio Pietro, Diociaiuti Marco, Luciani Paola, Mancini Giovanna, Mazzuca Claudia, Marra Manuela, Molinari Agnese, Monti Donato, Toccacieli Laura, Venanzi Mariano

机构信息

CNR Istituto di Metodologie Chimiche-Sezione Meccanismi di Reazione, and Dipartimento di Chimica, Università degli Studi di Roma "La Sapienza", P.le A. Moro 5, I-00185 Roma, Italy.

出版信息

J Med Chem. 2005 Jul 28;48(15):4882-91. doi: 10.1021/jm050182d.

DOI:10.1021/jm050182d

PMID:16033268

Abstract

Mixed cationic liposomes composed by different ratios of dimyristoyl-sn-glycero-phosphatidylcoline (DMPC) and a cationic gemini surfactant have been studied by various physicochemical tools as vehicles for m-tetrahydroxyphenylchlorin (m-THPC), a photosensitizer used in photodynamic therapy. Entrapment and location of m-THPC within the lipid double layer have been evaluated by different techniques and the new formulations have been tested on a stabilized cell line from a human colon tumor, COLO206. A correlation between the physicochemical features of formulations and their efficiency as photosensitizers vector was found.

摘要

由不同比例的二肉豆蔻酰 - sn - 甘油 - 磷脂酰胆碱（DMPC）和一种阳离子双子表面活性剂组成的混合阳离子脂质体，已通过各种物理化学工具进行研究，作为用于光动力疗法的光敏剂间四羟基苯基二氢卟酚（m - THPC）的载体。已通过不同技术评估了m - THPC在脂质双层中的包封和定位，并且在源自人结肠肿瘤的稳定细胞系COLO206上对新制剂进行了测试。发现制剂的物理化学特征与其作为光敏剂载体的效率之间存在相关性。