微小隐孢子虫的重组蛋白可诱导感染小鼠肠系膜淋巴结细胞增殖。
Recombinant proteins of Cryptosporidium parvum induce proliferation of mesenteric lymph node cells in infected mice.
作者信息
Singh Inderpal, Theodos Cynthia, Tzipori Saul
机构信息
Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA.
出版信息
Infect Immun. 2005 Aug;73(8):5245-8. doi: 10.1128/IAI.73.8.5245-5248.2005.
Abstract
Recombinant antigens of Cryptosporidium parvum, Cp900 and Cp40 but not Cp15, stimulated C. parvum-specific proliferative immune responses of mesenteric lymph node cells in C57BL/6J mice infected with different isolates (MD, GCH1, UCP, and IOWA) of C. parvum, indicating that both Cp900 and Cp40 are immunodominant targets of cellular immune responses during C. parvum infection.
摘要
微小隐孢子虫的重组抗原Cp900和Cp40（而非Cp15），可刺激感染了微小隐孢子虫不同分离株（MD、GCH1、UCP和IOWA）的C57BL/6J小鼠肠系膜淋巴结细胞的微小隐孢子虫特异性增殖免疫反应，这表明Cp900和Cp40都是微小隐孢子虫感染期间细胞免疫反应的免疫显性靶点。
相似文献
1
Recombinant proteins of Cryptosporidium parvum induce proliferation of mesenteric lymph node cells in infected mice.
Infect Immun. 2005 Aug;73(8):5245-8. doi: 10.1128/IAI.73.8.5245-5248.2005.
2
A 23-kDa recombinant antigen of Cryptosporidium parvum induces a cellular immune response on in vitro stimulated spleen and mesenteric lymph node cells from infected mice.
Exp Parasitol. 2000 Sep;96(1):32-41. doi: 10.1006/expr.2000.4545.
3
Expression of the recombinant fusion protein CP15-23 of Cryptosporidium parvum and its protective test.
J Nanosci Nanotechnol. 2005 Aug;5(8):1292-6. doi: 10.1166/jnn.2005.210.
4
Cloning and expression of a cDNA encoding epitopes shared by 15- and 60-kilodalton proteins of Cryptosporidium parvum sporozoites.
Infect Immun. 1993 Jun;61(6):2377-82. doi: 10.1128/iai.61.6.2377-2382.1993.
5
Comparison of the humoral and cellular immune responses to two preparations of Cryptosporidium parvum CP15/60 recombinant protein.
Microb Pathog. 1999 Jun;26(6):307-15. doi: 10.1006/mpat.1999.0276.
6
Expression of Cpgp40/15 in Toxoplasma gondii: a surrogate system for the study of Cryptosporidium glycoprotein antigens.
Infect Immun. 2003 Oct;71(10):6027-34. doi: 10.1128/IAI.71.10.6027-6034.2003.
7
The humoral and cellular immune responses in mice induced by DNA vaccine expressing the sporozoite surface protein of Cryptosporidium parvum.
DNA Cell Biol. 2004 May;23(5):335-9. doi: 10.1089/104454904323090967.
8
Cloning of the immunodominant 17-kDa antigen from Cryptosporidium parvum.
Mol Biochem Parasitol. 2000 Mar 5;106(2):261-71. doi: 10.1016/s0166-6851(99)00223-6.
9
Mucosal cytokine and antigen-specific responses to Cryptosporidium parvum in IL-12p40 KO mice.
Parasite Immunol. 2005 Jan-Feb;27(1-2):17-28. doi: 10.1111/j.1365-3024.2005.00736.x.
10
The immunological selection of recombinant peptides from Cryptosporidium parvum reveals 14 proteins expressed at the sporozoite stage, 7 of which are conserved in other apicomplexa.
Mol Biochem Parasitol. 2007 Apr;152(2):159-69. doi: 10.1016/j.molbiopara.2006.12.010. Epub 2007 Jan 7.
引用本文的文献
1
mA mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection.
Front Immunol. 2021 Jul 6;12:705232. doi: 10.3389/fimmu.2021.705232. eCollection 2021.
2
Identification and characterization of a new 34 kDa MORN motif-containing sporozoite surface-exposed protein, Cp-P34, unique to Cryptosporidium.
Int J Parasitol. 2021 Aug;51(9):761-775. doi: 10.1016/j.ijpara.2021.01.003. Epub 2021 Mar 25.
3
Systemic and Mucosal Immune Responses to -Vaccine Development.
Curr Trop Med Rep. 2015 Sep 1;2(3):171-180. doi: 10.1007/s40475-015-0054-y.
4
Large, rapidly evolving gene families are at the forefront of host-parasite interactions in Apicomplexa.
Parasitology. 2015 Feb;142 Suppl 1(Suppl 1):S57-70. doi: 10.1017/S0031182014001528. Epub 2014 Sep 26.
5
Serum IgG response to Cryptosporidium immunodominant antigen gp15 and polymorphic antigen gp40 in children with cryptosporidiosis in South India.
Clin Vaccine Immunol. 2011 Apr;18(4):633-9. doi: 10.1128/CVI.00464-10. Epub 2011 Feb 2.
6
Oral immunization with attenuated Salmonella enterica serovar Typhimurium encoding Cryptosporidium parvum Cp23 and Cp40 antigens induces a specific immune response in mice.
Clin Vaccine Immunol. 2009 Sep;16(9):1272-8. doi: 10.1128/CVI.00089-09. Epub 2009 Jul 15.
本文引用的文献
1
Complete genome sequence of the apicomplexan, Cryptosporidium parvum.
Science. 2004 Apr 16;304(5669):441-5. doi: 10.1126/science.1094786. Epub 2004 Mar 25.
2
Infectivity of a Cryptosporidium parvum isolate of cervine origin for healthy adults and interferon-gamma knockout mice.
J Infect Dis. 2002 May 1;185(9):1320-5. doi: 10.1086/340132. Epub 2002 Apr 16.
3
Characterization of a major sporozoite surface glycoprotein of Cryptosporidum parvum.
Funct Integr Genomics. 2000 Nov;1(3):207-17. doi: 10.1007/s101420000028.
4
A 23-kDa recombinant antigen of Cryptosporidium parvum induces a cellular immune response on in vitro stimulated spleen and mesenteric lymph node cells from infected mice.
Exp Parasitol. 2000 Sep;96(1):32-41. doi: 10.1006/expr.2000.4545.
5
Mediation of Cryptosporidium parvum infection in vitro by mucin-like glycoproteins defined by a neutralizing monoclonal antibody.
Infect Immun. 2000 Sep;68(9):5167-75. doi: 10.1128/IAI.68.9.5167-5175.2000.
6
Molecular cloning and expression of a gene encoding Cryptosporidium parvum glycoproteins gp40 and gp15.
Infect Immun. 2000 Jul;68(7):4108-16. doi: 10.1128/IAI.68.7.4108-4116.2000.
7
Cytokine expression and specific lymphocyte proliferation in two strains of Cryptosporidium parvum-infected gamma-interferon knockout mice.
J Parasitol. 2000 Apr;86(2):300-7. doi: 10.1645/0022-3395(2000)086[0300:CEASLP]2.0.CO;2.
8
Nasal immunization of mice with Cryptosporidium parvum DNA induces systemic and intestinal immune responses.
Parasite Immunol. 1999 Oct;21(10):507-16. doi: 10.1046/j.1365-3024.1999.00247.x.
9
Protection of calves against cryptosporidiosis with immune bovine colostrum induced by a Cryptosporidium parvum recombinant protein.
Vaccine. 1999 Apr 23;17(17):2142-9. doi: 10.1016/s0264-410x(98)00477-0.
10
Comparison of the humoral and cellular immune responses to two preparations of Cryptosporidium parvum CP15/60 recombinant protein.
Microb Pathog. 1999 Jun;26(6):307-15. doi: 10.1006/mpat.1999.0276.
Zotero 插件