甲状腺功能减退患者左甲状腺素替代治疗前后骨保护素血浆浓度的变化。
Changes in plasma concentrations of osteoprotegerin before and after levothyroxine replacement therapy in hypothyroid patients.
作者信息
Guang-da Xiang, Hui-ling Sun, Zhi-song Cheng, Lin-shuang Zhao
机构信息
Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan 430070, Hubei Province, People's Republic of China.
出版信息
J Clin Endocrinol Metab. 2005 Oct;90(10):5765-8. doi: 10.1210/jc.2005-0562. Epub 2005 Jul 26.
CONTEXT
Recent study has shown that overt hypothyroidism (oHT) is associated with increased plasma osteoprotegerin (OPG) levels.
OBJECTIVE
Our objective was to examine the plasma OPG level alteration before and after levothyroxine (L-T4) treatment in oHT and subclinical hypothyroidism (sHT).
PATIENTS
The study subjects included oHT and sHT patients and healthy individuals (20 subjects in each group).
METHODS
All patients were given L-T4 therapy to maintain a euthyroid state. Plasma OPG concentration was measured in duplicate by a sandwich ELISA.
RESULTS
Plasma OPG levels in oHT and sHT before treatment were significantly higher than levels in controls (P < 0.01). After normalization of thyroid function, OPG levels in both groups decreased markedly (P < 0.01). The absolute changes in OPG showed a significant positive correlation with the changes in TSH (P < 0.05) and negative correlation with the changes in endothelium-dependent arterial dilation (P < 0.01) in hypothyroid patients during the course of treatment.
CONCLUSION
OPG may be involved in the development of vascular dysfunction in hypothyroid patients.
背景
最近的研究表明，显性甲状腺功能减退症（oHT）与血浆骨保护素（OPG）水平升高有关。
目的
我们的目的是研究oHT和亚临床甲状腺功能减退症（sHT）患者在左甲状腺素（L-T4）治疗前后血浆OPG水平的变化。
患者
研究对象包括oHT和sHT患者以及健康个体（每组20名受试者）。
方法
所有患者均接受L-T4治疗以维持甲状腺功能正常状态。采用夹心ELISA法重复测量血浆OPG浓度。
结果
治疗前oHT和sHT患者的血浆OPG水平显著高于对照组（P<0.01）。甲状腺功能恢复正常后，两组的OPG水平均显著下降（P<0.01）。在治疗过程中，甲状腺功能减退患者的OPG绝对变化与促甲状腺激素（TSH）变化呈显著正相关（P<0.05），与内皮依赖性动脉扩张变化呈负相关（P<0.01）。
结论
OPG可能参与甲状腺功能减退患者血管功能障碍的发生发展。
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