Stilbenophane analogues of deoxycombretastatin A-4.

作者信息

Mateo Carmen, Pérez-Melero Concepción, Peláez Rafael, Medarde Manuel

机构信息

Laboratorio de Química Orgánica y Farmacéutica, Universidad de Salamanca, Facultad de Farmacia, Campus Miguel de Unamuno, E-37007, Salamanca, Spain.

出版信息

J Org Chem. 2005 Aug 5;70(16):6544-7. doi: 10.1021/jo0508393.

DOI:10.1021/jo0508393

PMID:16050729

Abstract

A new family of polyoxygenated stilbenophanes has been synthesized as conformationally restricted analogues of antimitotic combretastatins. By means of the McMurry olefination process, compounds derived from diethyleneglycol and 1,6-hexanediol were obtained, whereas Grubbs' catalyst failed in producing the ring-closing metathesis to this kind of macrocyclic products.

摘要