Luoni G, Forton J, Jallow M, Sadighi Akha E, Sisay-Joof F, Pinder M, Hanchard N, Herbert M, Kimber M, Mott R, Hull J, Rockett K, Kwiatkowski D
University Department of Paediatrics, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, Oxon OX3 7BN, UK.
Genes Immun. 2005 Dec;6(8):723-7. doi: 10.1038/sj.gene.6364250.
Linkage disequilibrium across the human genome is generally lower in West Africans than Europeans. However in the 5q31 region, which is rich in immune genes, we find significantly more examples of apparent nonrecombination between distant marker pairs in West Africans. Much of this effect is due to SNPs that are absent in Europeans, possibly reflecting recent positive selection in the West African population.
全人类基因组中的连锁不平衡在西非人群中通常低于欧洲人群。然而，在富含免疫基因的5q31区域，我们发现西非人群中远距离标记对之间明显的非重组实例要多得多。这种效应很大程度上归因于欧洲人群中不存在的单核苷酸多态性（SNPs），这可能反映了西非人群近期经历了正向选择。
