影响口腔癌患者生存的因素：澳大利亚视角
Factors affecting survival in patients with oral cancer: an Australian perspective.
作者信息
Chandu A, Adams G, Smith A C H
机构信息
Oral and Maxillofacial Surgery, Austin Health, Burgundy St., Heidelberg 3084, Vic., Australia.
出版信息
Int J Oral Maxillofac Surg. 2005 Jul;34(5):514-20. doi: 10.1016/j.ijom.2004.10.006.
Little is known regarding disease-specific cumulative survival and factors affecting survival in Australian populations with oral squamous cell carcinoma. Kaplan Meier and Cox proportional hazards models were used to determine survival factors in 116 consecutive patients treated surgically at a single institution. Overall 5-year disease-specific survival rate was 83.3%. Five-year disease-specific survival probability was 88.7%, 83.8%, 83.3% and 76.5% for stage I, II, III and IV, respectively. Univariate analysis revealed that local and regional recurrence, distant metastases, N stage, margin status, radiotherapy, perivascular spread and extra-capsular spread (ECS) significantly influenced survival. Significant multivariate factors included local and regional recurrence, positive margins, and ECS. Better survival rates were found than in previous, older Australian reports. Close observation for early recurrence and aggressive management of patients with recurrence, positive margins and ECS, is advised.
关于澳大利亚口腔鳞状细胞癌患者的疾病特异性累积生存率以及影响生存率的因素，目前所知甚少。采用Kaplan Meier和Cox比例风险模型来确定在单一机构接受手术治疗的116例连续患者的生存因素。总体5年疾病特异性生存率为83.3%。I期、II期、III期和IV期的5年疾病特异性生存概率分别为88.7%、83.8%、83.3%和76.5%。单因素分析显示，局部和区域复发、远处转移、N分期、切缘状态、放疗、血管周围扩散和包膜外扩散（ECS）对生存率有显著影响。多因素分析的显著因素包括局部和区域复发、切缘阳性以及ECS。研究发现生存率高于澳大利亚以往较早的报告。建议对早期复发进行密切观察，并对复发、切缘阳性和ECS患者进行积极治疗。
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