MEN信号传导：子细胞附着的极必须脱离母细胞才能完全激活。

MEN signaling: daughter bound pole must escape her mother to be fully active.

作者信息

Yoshida Satoshi, Guillet Marie, Pellman David

机构信息

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Dev Cell. 2005 Aug;9(2):168-70. doi: 10.1016/j.devcel.2005.07.006.

DOI:10.1016/j.devcel.2005.07.006

PMID:16054023

Abstract

Budding yeast divide asymmetrically and must therefore align the position of the mitotic spindle with the plane of division. The success of this process is monitored by a checkpoint-signaling mechanism. Two recent papers in Molecular Cell reveal an important new facet of this signal transduction pathway.

摘要

出芽酵母进行不对称分裂，因此必须使有丝分裂纺锤体的位置与分裂平面对齐。这一过程的成功与否由一种检查点信号机制进行监测。《分子细胞》杂志最近发表的两篇论文揭示了这一信号转导途径一个重要的新方面。